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Roland Houben Selected Research

Tumor Viral Antigens (Large T Antigen)

1/2022Transduction-induced overexpression of Merkel cell T antigens in human hair follicles induces formation of pathological cell clusters with Merkel cell carcinoma-like phenotype.
1/2022Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth.
10/2020Merkel Cell Polyomavirus Large T Antigen is Dispensable in G2 and M-Phase to Promote Proliferation of Merkel Cell Carcinoma Cells.
4/2020Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma.
1/2020Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma.
1/2019Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration.
5/2018Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma.
1/2017Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome.
5/2016RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
3/2016Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells.
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Roland Houben Research Topics

Disease

40Neoplasms (Cancer)
02/2022 - 01/2004
29Merkel Cell Carcinoma
01/2022 - 05/2006
29Melanoma (Melanoma, Malignant)
12/2020 - 01/2004
5Carcinogenesis
04/2020 - 05/2010
4Disease Progression
03/2009 - 01/2004
3Neoplasm Metastasis (Metastasis)
01/2019 - 03/2009
2Skin Neoplasms (Skin Cancer)
10/2020 - 02/2012
2Experimental Melanoma
03/2009 - 01/2007
1Mycosis Fungoides
01/2022
1Malaria
04/2020
1Neuroendocrine Carcinoma
01/2019
1Carcinoma (Carcinomatosis)
01/2019
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
01/2019
1Lymphatic Metastasis
01/2017
1Nevus (Nevi)
01/2015
1Pseudolymphoma
11/2013
1Lymphoma (Lymphomas)
11/2013
1B-Cell Lymphoma (Lymphoma, B Cell)
11/2013
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
11/2013
1Leukemia
04/2012
1Oncogene Addiction
04/2012
1Uveal melanoma
01/2009
1Hematologic Neoplasms (Hematological Malignancy)
07/2008
1Breast Neoplasms (Breast Cancer)
07/2008
1Glioma (Gliomas)
07/2008

Drug/Important Bio-Agent (IBA)

17Tumor Viral Antigens (Large T Antigen)IBA
01/2022 - 07/2010
11Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2007
7Phosphotransferases (Kinase)IBA
01/2019 - 08/2004
6DNA (Deoxyribonucleic Acid)IBA
01/2019 - 01/2004
5RNA (Ribonucleic Acid)IBA
01/2020 - 07/2007
4Oncogene Proteins (Oncogene Protein)IBA
01/2022 - 01/2020
4Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2020 - 12/2005
4Messenger RNA (mRNA)IBA
09/2019 - 05/2010
4Retinoblastoma ProteinIBA
03/2016 - 02/2010
4Mitogen-Activated Protein KinasesIBA
06/2013 - 08/2008
3Pharmaceutical PreparationsIBA
04/2020 - 01/2006
3Matrix Metalloproteinases (MMPs)IBA
03/2009 - 03/2005
2NucleotidesIBA
01/2019 - 05/2010
2Keratin-20 (Cytokeratin 20)IBA
01/2019 - 05/2018
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2019 - 11/2013
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
09/2018 - 06/2013
2VemurafenibIBA
01/2017 - 06/2013
2Melanins (Melanin)IBA
01/2015 - 01/2014
2ParaffinIBA
01/2014 - 11/2013
2Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
01/2014 - 10/2013
2SurvivinIBA
06/2013 - 02/2009
1Cytotoxins (Cytolysins)IBA
02/2022
1Monoclonal AntibodiesIBA
02/2022
1Immunoconjugates (Immunoconjugate)IBA
02/2022
1Glycogen Synthase Kinase 3IBA
01/2022
1Brentuximab VedotinIBA
01/2022
1Histone MethyltransferasesIBA
04/2020
1ArtesunateIBA
04/2020
1Peptide Initiation Factors (Initiation Factor)IBA
01/2020
1N-methyladenosineIBA
01/2020
16-methyladenineIBA
01/2020
1Eukaryotic Initiation Factor-3IBA
01/2020
1Keratin-8 (Keratin 8)IBA
11/2019
1Immune Checkpoint InhibitorsIBA
09/2019
1ProteomeIBA
09/2019
1domatinostatIBA
01/2019
1tyrosine receptor (receptor, tyrosine)IBA
01/2019
1Fibroblast Growth Factor 1 (FGF-1)IBA
09/2018
1Thyroid Nuclear Factor 1IBA
05/2018
1pembrolizumabIBA
11/2017
1Phosphatidic Acids (Phosphatidic Acid)IBA
01/2017
1trametinibIBA
01/2017
1Phospholipase DIBA
01/2017
1Serine (L-Serine)FDA Link
03/2016
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2016
1EnzymesIBA
01/2016
1Monophenol Monooxygenase (Tyrosinase)IBA
01/2014
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
11/2013
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
11/2013
1nutlin 3IBA
10/2013
1UbiquitinIBA
10/2013
1Ligases (Synthetase)IBA
10/2013
1Threonine (L-Threonine)FDA Link
01/2012
1Peptidylprolyl Isomerase (Prolyl Isomerase)IBA
09/2011
1alpha-MSHIBA
01/2011
1Small Interfering RNA (siRNA)IBA
01/2011
1MART-1 AntigenIBA
01/2011
15' Untranslated Regions (5' UTR)IBA
05/2010
1TetraspaninsIBA
05/2010
1Tumor Suppressor Protein p14ARF (p14ARF)IBA
03/2009
1Sorafenib (BAY 43-9006)FDA Link
02/2009
1Imatinib Mesylate (Gleevec)FDA Link
01/2009
1Indicators and Reagents (Reagents)IBA
08/2008
1Phosphatidylethanolamine Binding ProteinIBA
08/2008
1N 30IBA
07/2008
1trans-sodium crocetinate (crocetin)IBA
07/2008
1ChemokinesIBA
05/2008
1Biomarkers (Surrogate Marker)IBA
11/2007
1Adenosine Triphosphate (ATP)IBA
11/2007
1Microphthalmia-Associated Transcription FactorIBA
11/2007
1N- (5- (3- dimethylaminobenzamido)- 2- methylphenyl)- 4- hydroxybenzamideIBA
09/2007

Therapy/Procedure

13Therapeutics
02/2022 - 10/2005
5Immunotherapy
12/2020 - 07/2007
2Transplantation
02/2012 - 02/2010
1Drug Therapy (Chemotherapy)
11/2007